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What is the most important information I should know about Nembutal (pentobarbital)? You should not use this medication if you are allergic to pentobarbital, or if you have porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system). Before using pentobarbital, tell your doctor if you have liver or kidney disease, chronic pain, severe or uncontrolled asthma or COPD, a history of mental illness or suicide attempt, or a history of addiction to drugs or alcohol. Pentobarbital may be habit-forming and should be used only by the person it was prescribed for. Pentobarbital should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Pentobarbital can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. Alcohol can also add to sleepiness caused by pentobarbital. Pentobarbital can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using pentobarbital.