Pentobarbital (Nembutal ®)
|Disclaimer: The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither Kontinental Pharmacy. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user’s use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.|
Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|Maximum rate: 50 mg/min
[100 mg] [50 ml]
[500 – 2000 mg] [250 ml](Concentrations from 0.5 to 8 mg/ml appear to be stable)
Infusion rate: As directed.
Stability / Miscellaneous
|EXP: 12 to 24 hrs (RT) variable (Review specialized reference for additional info).
Label: Do not refrigerate.Onset: 15-60 min
(Oral): 1-4 hrs (IV): 15 minMay be given deep IM (max 250mg per site) or by slow IV injection. Note: can be given IV undiluted.
Preoperative sedation: IM: 150-200 mg.
Barbiturate coma in head injury patients: IV loading dose of 5-10 mg/kg over 1 to 2 hours. Maintenance: Initial: 1 mg/kg/hr; may increase to 2-3 mg/kg/hr. Monitor for dose-dependent cardiovascular and respiratory depression. Maintain serum concentration at 2-4 mg/dl.
Supplied: 50mg/ml-1ml, 2 ml, 20ml, 50ml. (C-II)
DOSAGE AND ADMINISTRATION
There is no average intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that can be relied on to produce similar effects in different patients. The possibility of overdose and respiratory depression is remote when the drug is injected slowly in fractional doses.
A commonly used initial dose for the 70 kg adult is 100 mg. Proportional reduction in dosage should be made for pediatric or debilitated patients. At least one minute is necessary to determine the full effect of intravenous pentobarbital. If necessary, additional small increments of the drug may be given up to a total of from 200 to 500 mg for normal adults.
Special patient population